Retina Regeneration Therapy (Ellex 2RT™) is a research project aimed at developing a non-damaging laser treatment that stimulates the retinal pigment epithelium (RPE) to preserve vision. As a possible therapy for early age-related macular degeneration (AMD) and other retinal diseases, Ellex 2RT™ aims to treat the cause of the disease, before vision loss occurs.

If successful, Ellex 2RT™ will significantly improve the quality of life of millions of elderly people and reduce health care expenditure worldwide.

Initial laboratory studies successfully demonstrated that Ellex 2RT™ can be used to influence the early cause of AMD by triggering a cell regeneration process to improve the transport properties of Bruch’s membrane and thereby partially reverse the degradation that could lead to Wet or Dry AMD. Further laboratory studies measuring the hydroconductivity of Bruch’s membrane have also shown that Ellex 2RT™ rejuvenates the whole transport mechanism of the retina. Clinical trials are currently underway to validate the efficacy of Ellex 2RT™ for a number of clinical indications, the most important of which is AMD, and we look forward to updating you on our progress.

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Ellex 2RT in the Media

CAN EARLY LASER THERAPY DELAY DISEASE PROGRESSION?

Retinal Physician, September, 2009
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ELLEX LOOKS TO LASER RETINA REGENERATION THERAPY AS FUTURE FOR TREATING MACULOPATHY AND AMD

EuroTimes, January, 2009
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STUDY SHOWS ELLEX 2RT SAFE, EFFECTIVE FOR TREATING DIABETIC MACULAR EDEMA

OSN SuperSite, November, 2008
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LASER TREATMENT SHOWS PROMISE FOR DIABETIC MACULAR EDEMA

Retina Today, July/August 2008
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NEW LASER THERAPY QUICKLY HALTS DIABETIC MACULOPATHY: 2RT TREATS DISEASE EARLY & LEAVES PHOTORECEPTORS UNHARMED

Ophthalmology Times Europe, April 2008
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USING LASER THERAPY FOR DIABETIC MACULOPATHY AND AMD

Ophthalmology Times, November 2007
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IRV ARONS' JOURNAL

Irving Arons spent more than 30 years as a consultant to the ophthalmology industry, and more than 20 years as a medical laser industry consultant before retiring in 2005. Since then, he has continued to follow and comment on notable industry research, events and other topics in his blog, “Irv Aron’s Journal.” Late in 2007, he included a lengthy entry about 2RT research, writing, in part, “In looking further into this technique, I became convinced that, although it was very early in its development, it held the potential to become an important treatment in the armamentarium of retinal physicians."
Read the entire blog entry here.

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Press Releases

13 NOV 2009
ELLEX 2RT™ RESEARCH PROGRAM AWARDED GOVERNMENT GRANT

Ellex announced today that the Ellex 2RT™ Research Program has been awarded a $0.54 million Victorian Government grant.
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10 NOV 2008
ELLEX ANNOUNCES SIX-MONTH RESULTS ON RETINA REGENERATION THERAPY

Ellex today announced the six-month clinical study results for the groundbreaking treatment Retina Regeneration Therapy (Ellex 2RT™).  
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10 NOV 2007
ELLEX 2RT STUDY DEMONSTRATES CLINICAL EFFICACY IN TREATMENT OF DIABETIC MACULAR EDEMA

Ellex today announced clinical results of an ongoing study for non-thermal Retina Regeneration Therapy (Ellex 2RT™).
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1 NOV 2007
ELLEX ANNOUNCES NEW RETINA REGENERATION THERAPY TO BE PRESENTED AT THE AAO

Ellex today announced that the initial results of treating patients with Retina Regeneration Therapy (Ellex 2RT™) will be presented by Peter Hamilton MD, FRCOph at the annual meeting of the American Academy of Ophthalmology.
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Presentations

Selective Retinal Pigment Epithelial Treatment for Diabetic Macular Oedema: Six Month Results
Professor John Marshall, PhD, Euretina 2009.

Retinal Damage Profiles and Cellular Responses to Laser Treatment: Comparison Between a Novel, Non-Thermal Laser and a Conventional Photocoagulator
G. Chidlow; J.P.M. Wood; R.J. Casson; M. Plunkett
ARVO Presentation Abstract - Sunday 3 May, 2009, 8:30am - 10:15am

Sequestration of MMPs 2&9 by Ageing Human Bruch's Membrane: Relevance to Functional Deterioration
A. Kumar; A. El-Osta; A.A. Hussain; J. Marshall.
ARVO Presentation Abstract - Tuesday 5 May, 2009, 1:45pm - 3:30pm

Divalent Metal Ion Chelation is Associated With the Activation and Release of Matrix Metalloproteinase-2 From Human Bruch's Membrane
Y. Lee; A.A. Hussain; J. Marshall.
ARVO Presentation Abstract - Tuesday 5 May, 2009, 1:45pm - 3:30pm

Effect of Sub-Threshold Laser Energy (Ellex 2RT) on the Matrix Metalloproteinase (MMP) Release Profile of RPE and the Diffusional Status of Underlying Bruch's Membrane
J. Zhang; Y. Sun; A. Hussain; J. Marshall.
ARVO Presentation Abstract - Tuesday 5 May, 2009, 1:45pm - 3:30pm

Level and Distribution Patterns of Active Matrix Metalloproteinase Enzymes (MMPs) in Ageing Human Bruch's Membrane
A.A. Hussain; A. Kumar; A. El-Osta; J. Marshall.
ARVO Presentation Abstract - Wednesday 6 May, 2009, 3:45pm - 5:30pm

Photoregeneration Therapy: Treatment of Diabetic Maculopathy. Six Months’ Clinical Trial Results
Professor John Marshall, PhD, American Academy of Ophthalmology (AAO) 2008.

 

WEBINARS

Prof. John Marshall Photoregeneration Therapy: Treatment of Diabetic Maculopathy. Six Months Clinical Trial Results
Professor John Marshall, PhD, American Academy of Ophthalmology (AAO) 2008.

After more than a year of clinical research, the much-anticipated follow-up results are available regarding Ellex 2RT (Retina Regeneration Therapy) and the treatment of diabetic macula edema.

"Photoregeneration" - Tissue Interaction and Mechanisms of Action
Professor John Marshall, PhD, American Academy of Ophthalmology (AAO) 2007.

Professor Marshall will explain the mechanisms of action behind Selective Laser Trabeculoplasty and their relationship to emerging non-thermal therapies for restoring retinal function.

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Register for Updates

To keep up-to-date on the Ellex 2RT™ Research Program, sign up for our email alert program.

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